Capcom has set the record straight when it comes to whether you will ever be able to run and gun in Resident Evil 5. The bottom line is you cannot walk while shooting. Period.
Taken from the blog post:
THE NEW CONTROL OPTIONS IN RESIDENT EVIL 5 DO NOT ALLOW YOU TO MOVE AND SHOOT SIMULTANEOUSLY. While RE5 is very action-heavy, the base RE game design mechanic of holding fast while shooting remains. This mechanic will be immediately familiar to any of the 36+ million people who have played previous Resident Evil games, but may require some mental readjustments by players who are new to the series.
In every Resident Evil game, there are always consequences for your actions; combat, while an important part of the game, requires a steady hand and the correct timing. Have you ever tried walking (much less running) while shooting? If you have, you’ll know how hard it is to hit a target while in motion. This design reinforces the importance of playing co-op, as having a partner watching your back is crucial for success in the game.
Let’s hope this puts an end to the rumor that Capcom may patch in run and gun gameplay. I know this is a deal breaker for a lot of you, but if you’ve ever played Resident Evil 4, you know it brings a lot of tension to the game that wouldn’t be there if you could run and shoot simultaneously.